The Ultrasound Medical and Industrial Laboratory (UMIL) works on developing Ultrasound-based techniques for both medical and industrial applications.

Some of the ongoing research in the UMIL includes:

  • Ultrasonic focused beams and metamaterials for tissue characterization and therapy.
  • Transcranial propagation of ultrasound for the opening of the blood-brain barrier.
  • Magneto-Motive Ultrasound Imaging and photoacoustics.
  • Ultrasonic technology applied to dentistry.
  • Piezoelectric transducers for medical and industrial applications.

Members

Francisco Camarena Femenía, PhD, Group leader.
José M. Benlloch, PhD, Prof.
Noé Jiménez González, PhD, PosDoc.
Sergio Jiménez Gambín, PhD student.
Miguel Company Arnalte, Technical Support.
Josep Rodríguez Sendra, PhD Student.
Álvaro Sáenz de Inestrillas, Technical support.

 

Contact:

Francisco Camarena Femenía, PhD. Group leader.

fcamarena@fis.upv.es

Projects

Ongoing projects

Ultrasonic focused beams and metamaterials for tissue characterization and therapy.

Ultrasound focused beams can be used for imaging or therapy.  In our group we make experiments and develop numerical codes to study the ultrasound propagation in biological tissue, from linear to non linear regime, in order to characterize the beam focus parameters as: FWHM, peak pressure, rarefaction, acoustic radiation force or intensity. These results allow to obtain elastography images by evaluating the ARF in the tissue. The purpose of this research line is to understand the mechanisms that affect the ultrasonic field and develop new techniques for imaging and therapy.

Transcranial propagation of ultrasound for the opening of the blood-brain barrier.

The blood-brain barrier (BBB) restricts the diffusion of microscopic objects, thus protecting the brain from infections. However, it also prevents the passage of therapeutic drugs. BBB disruption can be achieved by using transcranial focused ultrasound and microbubble injection in an effective, non-invasive, transient, localized and safe manner. Thus, the BBB opening enables drug delivering to specific areas of the brain, which is mandatory in research of treatments for Alzheimer’s or Parkinson’s diseases. In UMIL we develop simulations and experiments to define a protocol for the transcranial targeting of the hippocampus of an adult human by using a single-element focused transducer.

Magneto-Motive Ultrasound Imaging and photoacoustics.

*Funded byGeneralitat Valenciana AICO2016-108.

Magneto-Motive ultrasound imaging detects the presence of magnetic nanoparticles through their mechanical (i.e. motion) responses to an external magnetic excitation. Due to their weak diamagnetic properties, normal tissue constituents do not respond to the magnetic field. However, when tissue is labeled with magnetic nanoparticles, it tends to move towards the lower magnetic potential. The magnetically induced displacement within nanoparticles and the tissue associated with them is detectable by ultrasound imaging. We are already developing in our laboratory the first prototype for magnetic nanoparticle detection.

Ultrasonic technology applied to dentistry.

*Funded byUPV and IVIO.

In collaboration with the Valencian Institute of Dental Research (IVIO), within the framework of Cátedra IVIO-UPV, we develop new ultrasonic techniques for monitoring, diagnosis and treatment in the field of dentistry. At this moment we are trying to characterize the guided process of bone growing in an odontological implant.

Piezoelectric transducers for medical and industrial applications. 

Piezoelectricity phenomenon is the basis for the ultrasonic generation and detection. Our group develop transducers for medical and industrial applications both at low and high power. Pulse-echo, Langevin and focused transducers, horns and sensors are designed, built and characterized in our laboratory.

HIFU device.

Relevant Publications

Peer-reviewed publications:

Design and performance of a metal-shielded piezoelectric sensor
Á. Sáenz-de-Inestrillas, F. Camarena, M. Bou-Cabo, J. Barreiro, A. Reig, 
Sensors2017, 17(6), 1284. 10.3390/s17061284

Dynamic nonlinear focal shift in amplitude modulated moderately focused acoustic beams
N. Jimenez, F. Camarena, N. González-Salido,
Ultrasonics 1 (75) 106-114 (2016).10.1016/j.ultras.2016.11.021

Time-Domain Simulation of Ultrasound Propagation in a Tissue-Like Medium Based on the Resolution of the Nonlinear Acoustic Constitutive Relations,
N. Jimenez, F. Camarena, J. Redondo, V. Sánchez, E. Konofagou,
Acta acustica united with Acustica (12) 876 – 892 (2016). 10.3813/AAA.919002

Radiation-force-based estimation of acoustic attenuation using harmonic motion imaging (HMI) in phantoms and in vitro livers before and after HIFU ablation,
C. Jiangang, G. H. Hou, F. Marquet, Y. Han, F. Camarena, E. Konofagou,
Physics In Medicine And Biology (6)7499 – 7512 (2015). 10.1088/0031-9155/60/19/7499

Nonlinear focal shift beyond the geometrical focus in moderately focused acoustic beams,
F. Camarena, S. Adrián-Martínez, N. Jimenez, V. Sánchez,
Journal Of The Acoustical Society Of America, 2 (137), 1463 – 1472 (2013). 10.1121/1.4812865

Simulacion numérica de una cerámica piezoeléctrica,
G. González-Salido, M. Ferri, N. Jimenez, F. Camarena, R. Picó, J. Redondo, B. Roig,
Modelling in Science Education and Learning, 12 (6), 132 – 144 (2013).

Explicit finite-difference time-domain scheme for the simulation of 1-3 piezoelectric effect in axisymmetrical configurations,
M. Ferri, F. Camarena, J. Redondo, R. Picó, M. R. Avis.
Wave Motion, 6 (49), 569 – 584 (2012).10.1016/j.wavemoti.2012.03.007 

Propagación no lineal de haces de ultrasonidos a través del cráneo para la apertura de la barrera hematoencefálica,
N. Jimenez, F. Camarena, J. Redondo, B. Roig, R. Picó
Revista de Acústica (1)3 – 8 (2012). Premio Andrés Lara.

Ultrasonic evaluation of the hydration degree of the orange peel,
N. Jimenez, R. Picó, F. Camarena, J. Redondo, B. Roig,
Postharvest Biology And Technology (67)130 – 137(2012). 10.1016/j.postharvbio.2011.12.020

Conference proceedings:

Estudio de la mejora de sensibilidad de un sensor piezoeléctrico encapsulado utilizando resonadores acústicos y bocinas,
Sáenz de Inestrillas, J.M. Barreiro, J. Rodríguez,F. Camarena.
48º  Congreso español de acústica encuentro ibérico de acústica TECNIACÚSTICA. A Coruña, Spain (2017).

Caracterización de medios viscoelásticos mediante la técnica Magneto-Motive Ultrasound,
Company, S. Jiménez-Gambín, J.M. Benlloch, F. Camarena.
48º  Congreso español de acústica encuentro ibérico de acústica TECNIACÚSTICA. A Coruña, Spain (2017).

Estudio del BUA y del SOS en soluciones acuosas para aplicaciones odontológicas,
J.Rodríguez, A. Ladino, J. Faus, R. Picó, A. Sáenz de Inestrillas, F. Camarena,
48º  Congreso español de acústica encuentro ibérico de acústica TECNIACÚSTICA. A Coruña, Spain (2017).

Estudio numérico del protocolo de propagación transcraneal de ultrasonidos para la apertura de la barrera hematoencefálica en el hipocampo de humano
N.Jiménez-Gambín, N. Jiménez, M. Company, F. Camarena,
48º  Congreso español de acústica encuentro ibérico de acústica TECNIACÚSTICA. A Coruña, Spain (2017).

Fuerza de radiación en haces focalizados de ultrasonidos de amplitud modulada barrera hematoencefálica en el hipocampo de humano,
N. Jiménez, F. Camarena, N. González-Salido, S. Jiménez-Gambín.
48º  Congreso español de acústica encuentro ibérico de acústica TECNIACÚSTICA. A Coruña, Spain (2017).

Desarrollo de un sistema ultrasónico de potencia para aplicaciones médicas en animales pequeños
R. Bailén, F. Camarena, F. Camarena, S. Jiménez-Gambín, M. Company,
48º  Congreso español de acústica encuentro ibérico de acústica TECNIACÚSTICA. A Coruña, Spain (2017).

Study of aberrations at the focus of an ultrasonic beam due to the propagation across different areas of the skull,
N. Jiménez-Gambín, N. Jimenez, W. Shih-Ying Wu, E. Konofagou, F. Camarena,
5th International Symposium on Focused Ultrasound. North Bethesda, USA (2016).Journal of Therapeutic Ultrasound 2016 4(Suppl 1):76

Time-domain simulation of constitutive relations for nonlinear acoustics including relaxation for frequency power law attenuation media modelling,
N. Jimenez, F. Camarena, V. Sánchez, J. Redondo, E. Konofagou,
20th International Symposium on Nonlinear Acoustics. Lyon, France (2015).

Ultrasonic evaluation of the hydration degree of the orange peel,
N. Jimenez, F. Camarena, R. Picó, J. Redondo, A. Duclos, J.P. Groby,
Fruit structure. Angers, France (2015). 

Diseño de un sensor acustico-piezoelectrico con encapsulado metálico,
J. Barreiro, Á.Sáenz-de-Inestrillas, F. Camarena,
TECNIACUSTICA 2015. 46º Congreso Español de Acústica. 9º Congreso Ibérico de Acústica. Valencia, Spain (2015).

Piezoelectric Sensor Design with Metal Shield,
J. Barreiro, A. Sáenz-de-Inestrillas, F. Camarena,
Iberian COMSOL Multiphysics Conference 2015. Málaga, España.

Numerical Simulation of Piezoceramic Elements,
J. Barreiro, A. Sáenz-de-Inestrillas, F. Camarena,
Iberian COMSOL Multiphysics Conference 2015. Málaga, España.

Transcranial Propagation with an Ultrasonic Mono-Element Focused Transducer,
P.C. Iglesias,N. Jimenez, E. Konofagou, F. Camarena, J. Redondo,
43rd Annual Symposium of the Ultrasonic Industry Association. Madrid, Spain (2015).

On the Nonlinear Effects in Focused Ultrasound Beams with Frequency Power Law Attenuation,
N. Jimenez, J. Redondo, V. Sánchez, P.C. Iglesias; F. Camarena,
43rd Annual Symposium of the Ultrasonic Industry Association. Madrid, Spain (2015).

Nonlinear ultrasound simulations including complex frequency dependent attenuation,
N. Jimenez, J. Redondo,V. Sánchez, F. Camarena.
43rd Annual Symposium of the Ultrasonic Industry Association. Madrid, Spain (2015).

PhD thesis:

N. Jiménez, Nonlinear Acoustic Waves in Complex Media,Universitat Politecnica València, June 2015.