The priority activity of this group is the research of new techniques of image reconstruction for applications in the biomedical field, but also covers other areas such as detection of contaminants in food processing.This team is involved on the development of novel software algorithms for in vivo imaging of molecular signatures of diseases in humans and small laboratory animals. Our main interest is focused on design and development of new algorithms for medical imaging. That covers computerized tomography (CT), radiation emissions in the form of annihilation of positrons (Positron Emission Tomography, PET), single emitted gamma rays, both in Tomography (Single Photon Emission Computed Tomography, SPECT) and pattern classification

The goals of our research are to design software beyond the current state-of-the–art, in terms of sensitivity, spatial, energy, and temporal resolutions. The algorithms developed by our group aim to provide the best achievable image quality with the available data in the most efficient way in terms of computing time and quantitative accuracy.

Members

María Jose Rodríguez Alvarez, PhD, Group leader
Laura Moliner Martínez, PhD, PosDoc
José M. Benlloch, PhD, Prof.
Andres Larroza Santacruz, PhD, PosDoc
Juan Manuel Alvarez Gómez, PhD Student
Vicente Giménez Alventosa, PhD Student
Cristobal Rodero Gomez, PhD Student
Sebastián Sánchez Goez, PhD Student
Juan Carlos Valderas Rosón, Technical support

Contact:

María José Rodríguez Alvarez,

mjrodri@i3m.upv.es

Projects

Ongoing projects

Molecular imaging system for heart diagnostic under stress condition. TEC2016-79884-C2-2-R

The CARDIO-PET project aims to develop an innovative Positron Emission Tomography (PET) cardiac system that allows PET scanning and patient movement simultaneously. 3D positioning devices are used which transmit the patient’s chest location in motion to the data acquisition system. These data are included in the PET image reconstruction algorithm. This objective can only be achieved by the development of specific gamma radiation (hardware) PET modules and fast and accurate image reconstruction algorithms (software).

The ability to measure Flight Time (TOF) is a basic requirement of the CARDIO-PET system, in order to obtain tomographic images with a limited geometry system, where lack of angular sampling produces a lack of Uniformity in the response of the system causing artifacts in the generated image. Our objective is to achieve 350 ps FWHM in the temporal resolution of the TOF measurement of the CARDIO-PET system. The initial design of the CARDIO-PET system includes the use of monolithic LYSO scintillation crystals with SiPM type.

                                                              

Objective monitoring of cognitive impairment by amyloid image analysis. RTC-2016-5186-1

This project proposes the development of a PET system that incorporates new algorithms of classification that allow the analysis of β-amyloid as a mechanism to analyze the effectiveness of the drugs tested. The following elements will be developed:

  • Automatic classification algorithms of PET images, generated by β.-amyloid tracers, applied to Alzheimer’s disease
  • CADx (Computer Aided Diagnostic) clinical software, according to the international normative medical device software for IEC 62304, for use by Medical personnel in the automated diagnosis of Alzheimer’s disease.
  • Development of a head movement compensation / immobilization system of the patient to facilitate PET image acquisition of the brain.
  • Development of new PET image reconstruction algorithms (including compensation of movement if required), adapted to the use of multi-core graphics processors (GPUs)
  • Design and development of a brain PET prototype unit.
  • Validation of the system.

 

Past projects

 

Development of advanced technology for detection of strange materials and profile of textures INSIDEFOOD. RTC-2014-2065-2

The main objective of Insidefood is the development of an X-ray visualization and identification system for automatic detection of different geometries and densities presented by foods, for quality evaluation and possible contamination with foreign bodies. This development has been particularized in two non-marketable prototypes applied to two types of industries with very different needs which are the production of industrial bakery and the processing, selection, and packaging of citrus fruits.

Relevant Publications

Peer-reviewed publications:

Performance characteristics of the MAMMOCARE PET system based on NEMA standard,
L. Moliner, C. Correcher, D. Hellingman, J. Alamo, V. Carrilero, A. Orero, A.J. González, J.M. Benlloch,
Instrum. 2017 Jan 3;12(1):C01014–C01014

A novel semi-robotized device for high-precision 18 F-FDG-guided breast cancer biopsy,
D. Hellingman, S.C. Teixeira, M.L. Donswijk, E.J. Rijkhorst, L. Moliner, J. Alamo, C.E. Loo, R.A. Valdés Olmos, M.P.M. Stokkel,
Rev Esp Med Nucl Imagen Mol . 2017 May;36(3):158–65.

Biopsy system guided by positron emission tomography in real-time,
L. Moliner, J. Álamo, D. Hellingman, J.L. Peris, J. Gomez, P. Tattersall, V. Carrilero, A. Orero, C. Correcher, J.M. Benlloch, In: Kontos D, Flohr TG, Lo JY, editors. 2016. p. 97832H.

Demyelinating and ischemic brain diseases: detection algorithm through regular magnetic resonance images
D. Castillo, René Samaniego, Y. Jiménez, L. Cuenca, O. Vivanco, M. J. Rodríguez-Álvarez
SPIEDigitalLibrary.org/conference-proceedings-of-spie

Online image corrections applied to a dedicated breast PET,
L. Moliner, A.J. González, C. Correcher, J.M. Benlloch,
J. Instrum. 2016 Mar 16;11(3):C03035–C03035.

A new method for image reconstruction in computed tomography (CT) using QR-Decomposition: Image quality assessment
A. Iborra, M.J. Rodriguez-Alvarez, A. Soriano, F. Sanchez, A. Aguilar, P. Bellido, P. Conde, A.J. Gonzalez, L. Moliner, J.P. Rigla, S. Sanchez, M. Seimetz, J.C. Valderas, J.M. Benlloch,
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE; 2015. p. 1–4.

Noise Analysis in Computed Tomography (CT) Image Reconstruction using QR-Decomposition Algorithm,
A. Iborra, M.J. Rodriguez-Alvarez, A. Soriano, F. Sanchez, P. Bellido, P. Conde, E. Crespo, A.J. Gonzalez, L. Moliner, J.P. Rigla, M. Seimetz, L.F. Vidal, J.M. Benlloch,
IEEE Trans Nucl Sci . 2015 Jun;62(3):869–75.

Pixel size gradient detector for monolithic crystal PET systems,
L. Moliner, C. Correcher, A.J. Gonzalez, A. Aguilar, P. Bellido, P. Conde, L. Hernandez, A. Iborra, J.P. Rigla, M.J. Rodriguez-Alvarez, F. Sanchez, S. Sanchez, M. Seimetz, A. Soriano, J.M. Benlloch,
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) . IEEE; 2015. p. 1–4.

Expectation maximization (EM) algorithms using polar symmetries for computed tomography (CT) image reconstruction,
M.J. Rodríguez-Alvarez, A. Soriano, A. Iborra, F. Sánchez, A.J. González, P. Conde, L. Hernández, L. Moliner, A. Orero, L.F. Vidal, J.M. Benlloch,
Comput Biol Med . 2013 Sep;43(8):1053–61.

EM tomographic image reconstruction using polar voxels,
A. Soriano, M.J. Rodríguez-Alvarez, A. Iborra, F. Sánchez, M. Carles, P. Conde, A.J. González, L. Hernández, L. Moliner, A. Orero, L.F. Vidal, J.M. Benlloch,
J. Instrum . 2013 Jan 3;8(1):C01004–C01004.

Effect of noise in CT image reconstruction using QR-Decomposition algorithm,
A. Iborra, M. J. Rodríguez-Alvarez, A. Soriano, F. Sánchez, P. Bellido, P. Conde, E. Crespo, A. J. González, F. Martos, L. Moliner, J. P. Rigla, M. Seimetz, L. F. Vidal and J. M. Benlloch,
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC) . IEEE; 2013. p. 1–4.

Performance evaluation of the dual ring MAMMI breast PET,
A. Soriano, F. Sanchez, V. Carrilero, A. Pardo, L.F. Vidal, C. Vázquez, J. Barberá, M. Seimetz, M.J. Rodríguez-Alvarez, J.P. Rigla, L. Moliner, A. Iborra, L. Hernandez, A.J. González, E. Crespo, P. Conde, P. Bellido, L. Caballero, J.M. Benlloch,
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC). IEEE; 2013. p. 1–4. Available from

Time reconstruction study using tubes of response backprojectors in list mode algorithms, applied to a monolithic crystals based breast PET,
L. Moliner, C. Correcher, A. J. González, P. Conde, E. Crespo, L. Hernández, J.P. Rigla, M. J. Rodríguez-Álvarez, F. Sánchez, A. Soriano, A. Iborra, P. Bellido, M. Seimetz, L. F. Vidal, and J. M. Benlloch,
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC) . IEEE; 2013. p. 1–5.

Minimization of Parallax Error in Dedicated Breast PET,
A. Soriano, A.J. Gonzalez, F. Sanchez, P. Conde, L. Moliner, A. Orero, M.J. Rodriguez-Alvarez, L.F. Vidal, J.M. Benlloch,
IEEE Trans Nucl Sci . 2013 Apr;60(2):739–45.

Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET,
L. Moliner, C. Correcher, A.J. González, P. Conde, L. Hernández, A. Orero, M.J. Rodríguez-Álvarez, F. Sánchez, A. Soriano, L.F. Vidal, J.M. Benlloch,
Nucl InstrumentsMethods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip . 2013 Feb;702:129–32.

Design and evaluation of the MAMMI dedicated breast PET,
L. Moliner, A.J. González, A. Soriano, F. Sánchez, C. Correcher, A. Orero, M. Carles, L.F. Vidal, J. Barberá, L. Caballero, M. Seimetz, C. Vázquez, J.M. Benlloch,
Med Phys . 2012 Aug 15;39(9):5393–404.

Exploiting symmetries for weight matrix design in CT imaging,
M.-J. Rodríguez-Alvarez, F. Sánchez, A. Soriano, A. Iborra, C. Mora,
Math Comput Model . 2011 Oct;54(7–8):1655–64.

Sparse Givens resolution of large system of linear equations: Applications to image reconstruction,
M.-J. Rodríguez-Alvarez, F. Sánchez, A. Soriano, A. Iborra,
Math Comput Model . 2010 Oct;52(7–8):1258–64.

New pixellation scheme for CT algebraic reconstruction to exploit matrix symmetries,
C. Mora, M.J. Rodríguez-Álvarez, J.V. Romero,
Comput Math with Appl . 2008 Aug;56(3):715–26. Available from:

Performance characteristics of the MAMMI PEMT scanner based on NEMA NU 2-2007.
L. Moliner, J.M. Benlloch, M. Carles, C. Correcher, A.J. Gonzalez, A. Orero, F. Sanchez, A. Soriano,
IEEE Nuclear Science Symposuim & Medical Imaging Conference . IEEE; 2010. p. 2591–4.

Performance tests of two portable mini gamma cameras for medical applications,
F. Sánchez, M.M. Fernández, M. Giménez, J.M. Benlloch, M.J. Rodríguez-Alvarez, F. García de Quirós, C.W. Lerche, N. Pavón, J.A. Palazón, J. Martínez, A. Sebastiá,
Med Phys . 2006 Oct 19;33(11):4210–20.

Doctoral Thesis:

Amadeo Iborra Carreres, Development of a new 3D reconstruction algorithm for computed tomography (CT), Universitat Politecnica de Valencia.Supervisors: María José Rodríguez Álvarez and Antonio Soriano Asensi. Año 2015

Monserrat Carles Fariñas, Optimización y caracterización de la calidad de imagen en tomografía por emisión de positrones,University of Valencia
Supervisors: María José Rodríguez Álvarez and Christoph Lerche. Año 2012

María Teresa Mora Mora,Métodos de reconstrucción volumétrica algebraica de imágenes tomográficas. Aplicación a un TAC de pequeños animales y a un simulador TAC. Universitat Politecnica de Valencia
Supervisors: María José Rodríguez Álvarez and Rafael Jacinto Villanueva Micó. Año 2008

On going doctoral thesis:

Sebastián Sánchez Goez,Nuevos Algoritmos y correcciones en reconstrucción directa de imagen PET, Universitat Politecnica de Valencia
Supervisor : María José Rodríguez Alvarez and Antonio Javier González

Master and degree thesis

Santiago Pérez Romero,Segmentación 3D de imágenes médicas de tomografía por emisión de positrones  (PET), Universitat Politecnica de Valenica. 14/09/2016.
Supervisor: María José Rodríguez Alvarez.

Javier Ruíz Baragaño, Modelización de la epidemia de la Gripe A (H1N1) mediante redes aleatorias en un entorno de computación distribuida, Universitat Politecnica de Valencia. 28/09/2012.
Supervisor: María José Rodríguez Alvarez and Rafael Jacinto Villanueva Micó.

Amadeo Iborra Carreres, Estudio de simetrías en el diseño de la matriz de pesos para imágenes TAC, Universitat Politecnica de Valencia. 28/06/2011.
Supervisors: María José Rodríguez Alvarez and Rafael Jacinto Villanueva Micó.

Amadeo Iborra Carreres, Reconstrucción de alta resolución en tomografía axial computerizada, Universitat Politecnica de Valencia. 28/09/2010.
Supervisor: María José Rodríguez Alvarez and Rafael Jacinto Villanueva Micó.

José Francisco Pomares Sanz, Cálculo de soluciones analítico numéricas de problemas de difusión mixtos singulares acoplados, Universitat Politecnica de Valencia, 22/06/2000.
Supervisors: María José Rodríguez Alvarez and Rafael Jacinto Villanueva Micó.

José Gisbert Cano, Extractor de datos de RETAIN, Universitat Politecnica de Valencia, 18/02/2000.
Supervisor: María José Rodríguez Alvarez and Rafael Jacinto Villanueva Micó.

José Roman Panicello Wiergo, Autoaprendizaje de inversas generalizadas con Mathematica, Universitat Politecnica de Valencia.14/02/2000.
Supervisor: María José Rodríguez Alvarez and Rafael Jacinto Villanueva Micó.

Ramon Ferrer Olmos, Autoaprendizaje de matrices y determinantes con Mathematica, Universitat Politecnica de Valencia. 14/02/2000.
Supervisors: María José Rodríguez Alvarez and Rafael Jacinto Villanueva Micó.